Hydroxyphenobarbital
WebAs part of an investigation of phenobarbital (PB) pharmacokinetics in patients with status epilepticus (SE), urinary excretion of PB and its main metabolite, hydroxyphenobarbital (HPB), was studied in patients who had an episode of SE, as well as in non-convulsing ones. Eleven in-patients were studied: (group 1) five patients (4 M+1 F; 48±28 years old; … WebA sensitive and efficient analytical procedure was developed to determine phenobarbital-N-glucoside, phenobar bital and p-hydroxyphenobarbitals in urine. A sensitive and efficient analytical procedure was developed to determine phenobarbital-N-glucoside, phenobarbital and p-hydroxyphenobarbital in urine. The stable-isotope labeled internal standards …
Hydroxyphenobarbital
Did you know?
Web1 okt. 1980 · A sensitive and specific GLC–chemical-ionization mass spectrometric method was developed for the simultaneous assay of phenobarbital (I) and p-hydroxyphenobarbital (II) in biological fluids (urine and plasma) using stable isotope analogs of the compounds as internal standards.After extraction, the compounds were … Web30 apr. 2012 · Presentation Transcript. METABOLITE KINETICS I. SIGNIFICANCE OF DRUG METABOLITES Reproduced from: Houston JB. Drug metabolite kinetics. Pharmac Ther 15:521-552, 1982. CONSEQUENCES OF BIOTRANSFORMATION Active Drug to Inactive Metabolite hydroxylation Phenobarbital Hydroxyphenobarbital Active Drug to …
Webp-Hydroxyphenobarbital DBMET00111. Phenobarbital O-sulfate. DBMET01217. Reaction type Not Available Direction. Major circulating metabolite? No Spontaneous? No Activity unknown References. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in ... WebHydroxyphenobarbital. Molecular Formula C 12 H 12 N 2 O 4; Average mass 248.235 Da; Monoisotopic mass 248.079712 Da; ChemSpider ID 9402
WebBiotransformation of phenobarbital (PB) to p-hydroxyphenobarbital (PHPB) was studied quantitatively by gas-liquid chromatography in 8 epileptic patients who were receiving … Web1 apr. 1993 · Effect of phenobarbital andp-hydroxyphenobarbital glucuronide on acetaminophen metabolites in isolated rat hepatocytes: Use of a kinetic model to …
Web2 aug. 2010 · As part of an investigation of phenobarbital (PB) pharmacokinetics in patients with status epilepticus (SE), urinary excretion of PB and its main metabolite, hydroxyphenobarbital (HPB), was studied in patients who had an episode of SE, as well as in non-convulsing ones. Eleven in-patients were studied: (group 1) five patients (4 …
WebBiotransformation of phenobarbital (PB) to p-hydroxyphenobarbital (PHPB) was studied quantitatively by gas-liquid chromatography in 8 epileptic patients who were receiving an … box filter isotropicWebN2 - Biotransformation of phenobarbital (PB) to p hydroxyphenobarbital (PHPB) was studied quantitatively by gas liquid chromatography in 8 epileptic patients who were receiving an established regimen of antiepileptic drugs including PB. PB and both conjugated and unconjugated PHPB were present in each patient's urine; ... gupshup locationsWeb1 nov. 1981 · Analytical methodology was developed for the quantitation of p-hydroxyphenobarbital extracted from plasma, urine, and hepatic microsomes.p-Hydroxyphenobarbital was derivatized with an appropriate n-alkyl iodide in the presence of a methanolic base in aprotic solvent medium.The peralkylated derivatives were stable … gupshup mumbai officeWebA sensitive and efficient analytical procedure was developed to determine phenobarbital-N-glucoside, phenobarbital and p-hydroxyphenobarbital in urine. The stable-isotope … gupshup london ontarioWebThe present study examined the applicability of kinetic modeling in describing acetaminophen glucuronide (AG) and acetaminophen sulfate (AS) formation and egress in hepatocytes after acute exposure to phenobarbital or p-hydroxyphenobarbital glucuronide (p-OHPBG) in vitro, or in vivo phenobarbital pretreatment. gupshup newsWeb4-HYDROXYPHENOBARBITAL RF9R6T1NUN Other Structure General Names 12: Identifiers 6: Related Substances 1: 4-HYDROXYPHENOBARBITAL RF9R6T1NUN … box filzWeb11 apr. 1980 · The extracts were divided into two equal portions; one portion was ethylated by Greeley's method for the analysis of primidone, phenobarbital and hydroxyphenobarbital, while the other was trimethylsilylated for the analysis of primidone and PEMA. A gas chromatographic—mass spectrometric system was used for the … box filtro